(see section.3). The digoxin dose should be reduced by approximately 50, serum levels of digoxin should be closely monitored and clinical and ECG monitoring is recommended. Lauer-Taxe) bei Abgabe zu Lasten der gesetzlichen Krankenkassen (KK die sich gemäß 129 Abs. Their co-administration is contraindicated (see section.3). If an increase in creatininemia is observed, serum creatinine should be re-measured after a further 7 days.
Grapefruit and grapefruit juice may interact with dronedarone and lead to unwanted side effects. Lower starting dose and maintenance doses of statins should be considered and patients monitored for clinical signs of muscular toxicity. The effect of severe hepatic impairment on the pharmacokinetics of dronedarone was not assessed (see section.3). An increase in creatininemia should not necessarily lead to the discontinuation of treatment with ACE inhibitors or Angiotensin II Receptors Antagonists (aiiras).Larger increases in creatinine after dronedarone initiation have been reported in the postmarketing setting. Repeated doses of erythromycin (500 mg three times a day for 10 days) resulted in an increase in steady state dronedarone exposure.8-fold. Seek emergency medical attention or call the Poison Help line. Your liver and kidney function may also need to be checked. In such cases dronedarone should be stopped (see sections.3 and.4). Elimination After oral administration, approximately 6 of the labelled dose is excreted in urine mainly as metabolites (no unchanged compound excreted in urine) and 84 are excreted in faeces mainly as metabolites.
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