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patients and caregivers that geriatric patients with dementia-related psychosis treated with antipsychotic agents are at an increased risk of death. 1 10 In vitro, neither a clinically relevant substrate nor inhibitor of the efflux transporters P-glycoprotein (P-gp) and breast cancer resistance protein (bcrp organic anion transport proteins (oatp) 1B1 and 1B3, organic anion transporter 3 (OAT3 organic cation transporter 2 (OCT2 and multidrug and toxic. 1 39 73 (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis in Boxed Warning, see Cerebrovascular Events in Geriatric Patients with Dementia-related Psychosis under Cautions, and see Dysphagia under Cautions.) Worsening of Depression and Suicidality Risk Possible worsening of depression and/or emergence of suicidal. 1 Importance of informing patients of other important precautionary information. 1 Seizures Brexpiprazole may cause seizures. John's wort is discontinued 1 Ticlopidine No clinically important effect on brexpiprazole pharmacokinetics 1 10 Warfarin Clinically important interaction due to protein binding displacement of brexpiprazole unlikely 1 10 Rexulti Pharmacokinetics Absorption Bioavailability Peak plasma concentrations achieved within 4 hours following single-dose, oral administration. Oral antipsychotics for the treatment of schizophrenia: free coupons for popsicles heterogeneity in efficacy and tolerability should drive decision-making. 1 If manifestations of hyperglycemia occur in any brexpiprazole-treated patient, perform fasting blood glucose testing. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. In: Abstracts of the 1st International Conference on Therapeutic Risk Management and 19th International Conference on Pharmacoepidemiology, Philadelphia, PA, 2003 Aug 21-24.

Practice guideline for the treatment of patients with schizophrenia, second edition. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Appropriately monitor and closely observe patients receiving antidepressants for any reason, particularly during initiation of therapy (i.e., the first few months) and during periods of dosage adjustments. Oosterhof CA, El Mansari M, Blier. Consensus development conference on antipsychotic drugs and obesity and diabetes. (See Worsening of Depression and Suicidality Risk under Cautions.) Introduction Atypical or second-generation antipsychotic agent. Brexpiprazole Routes Dosage Forms Strengths Brand Names Manufacturer Oral Tablets.25 mg Rexulti Otsuka (also promoted by Lundbeck).5 mg Rexulti Otsuka (also promoted by Lundbeck) 1 mg Rexulti Otsuka (also promoted by Lundbeck) 2 mg Rexulti Otsuka (also promoted by Lundbeck) 3 mg Rexulti. In clinical trials in patients with schizophrenia, the incidence of EPS-related adverse reactions, excluding akathisia, was 5 (4 in placebo patients). 1 Orthostatic Hypotension and Syncope Risk of orthostatic hypotension and syncope with atypical antipsychotics, particularly during initial dosage titration and when dosage is increased, because of brexpiprazole's 1-adrenergic blocking activity. 28 Patients who do not respond to or tolerate one drug may be successfully treated with an agent from a different class or with a different adverse effect profile. 1 Poor Metabolizers of CYP2D6 Reduce brexpiprazole dosage. 1 Importance of advising patients about the signs and symptoms of tardive dyskinesia.


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